12/9/2014: Paper: Ruben Acuña, Zoé Lacroix, Nikolaos Papandreou, and Jacques Chomilier. Protein intrachain contact prediction with most interacting residues (MIR). Bio-Algorithms and Med-Systems 10 (4), 227-242.
11/19/2014: Presentation: Ruben Acuña, Zoé Lacroix, Jacques Chomilier, and Nikolaos Papandreou. SMIR: a method to predict the residues involved in the core of a protein. European Conference on Computational Biology 2014, 7 - 10 Sep 2014, E03. Now available online.
11/19/2014: Presentation: Ruben Acuña, Zoé Lacroix, and Jacques Chomilier. SPROUTS 2.0: a database and workflow to predict protein stability upon point mutation. European Conference on Computational Biology 2014, 7 - 10 Sep 2014, E01. Now available online.
09/21/2014: Statistics: SPROUTS now contains over 1800 entries.
07/22/2014: Presentation: Ruben Acuña, Zoé Lacroix, Jacques Chomilier, and Nikolaos Papandreou. SMIR: a method to predict the residues involved in the core of a protein. BIOCOMP '14.
06/12/2014: Statistics: SPROUTS now contains over 1600 entries - an increase of 373% from the initial 429 entries at the time of the public release on 05/03/2012. Since it was made available in May 2012, users from over 60 countries have visited and queried SPROUTS.
02/02/2014: Query Mode Improvements: A separate interface for quickly accessing SMIR/MIR has been added.
09/12/2013: Statistics: SPROUTS now contains over 900 entries.
07/01/2013: Server Improvements: SPROUTS has now been migrated to RPBS (Ressource Parisienne en Bioinformatique Structurale).
06/17/2013: New Paper: Ruben Acuña, Zoé Lacroix, and Jacques Chomilier: A Workflow for the Prediction of the Effects of Residue Substitution on Protein Stability. PRIB 2013, Eighth IAPR International Conference on Pattern Recognition in Bioinformatics.
06/10/2013: Query Mode Improvements: 1) The DDG viewing mode has been updated with a dynamic interface for selecting tools, smoothing, and impact type. 2) Publication quality (SVG) image downloads are now supported.
02/01/2013: New Tool: Smooth MIR. Results are available for existing entries.
12/21/2012: Query Mode Improvements: 1) Added DDG threshold support. The user may select from either 0.00 (which gives the same sign result as before), 1.00, or 2.00. This also introduces the concept of neutral residues which are not stabilizing or destabilizing. 2) Added support for arbitrary selection of tools. 3) Autocomplete now allows users to search by protein name.
12/20/2012: Over the past week query access to SPROUTS has been limited due to issued with our database; these problem should now be resolved. We apologize for the inconvenience.
07/25/2012: The entire website has been redesigned and implemented. TEF graphs are now available from the table view. There is also a new page for getting started.
07/20/2012: A new page has been added which shows graphically the number of proteins being submitted.
07/02/2012: New Poster: Ruben Acuña, Zoé Lacroix, and Jacques Chomilier: The SPROUTS Submission Workflow. JOBIM 2012.
06/24/2012: New Paper: Ruben Acuña, Zoé Lacroix, and Jacques Chomilier: Refurbishing Legacy Biological Workflows: SPROUTS Case Study. IEEE 2012 SERVICES Workshop on Scientific and Engineering Workflows.
06/06/2012: New Tools: Foldx 3.0 beta5.1, I-Mutant 3.06 sequence mode, and I-Mutant 3.0.6 structure mode.
05/03/2012: The submission server is now online for public testing.
02/03/2012: New Paper: Ruben Acuña, Zoé Lacroix, Fayez Hadji, Jacques Chomilier, Nikolaos Papandreou: Prediction of Chimeric Protein Fold. BIOINFORMATICS 2012.
12/06/2011: The submission database is now online, we will make submission publicly available once preliminary testing and upgrades are complete.
05/03/2011: We have resolved issues getting access to ASU's new web server. ASU's new policy prevents us running the database on their servers so submission is not available.
12/20/2010: Website is temporarily offline due to ASU web server upgrade.
11/05/2010: New Paper: Rida A. Bazzi, Jeffrey M. Kiefer, Zoé Lacroix: A User-Centric Classification of Tools for Biological Resource Discovery and Integration on the Web. RED 2010.
01/13/2009: Major update. Addition of 256 new proteins in the database.
01/01/2009: New Paper: Mathieu Lonquety, Zoé Lacroix, Nikolaos Papandreou, Jacques Chomilier: SPROUTS: a database for the evaluation of protein stability upon point mutation. Nucleic Acids Research 37(Database-Issue): 374-379 (2009). PMID: 18945702
10/15/2008: New Paper: Mathieu Lonquety, Zoé Lacroix, Jacques Chomilier: Evaluation of the Stability of Folding Nucleus upon Mutation. PRIB 2008.
10/01/2008: New Grant: CNS 0849980
04/11/2008: New database features have been released. The user can now visualize the TEF assignment and MIR prediction for each database sequence on the visualization pop-up.
03/11/2008: The 3D view mode is back online with a new feature: the stability score can be represented by a gradient of colors.
02/25/2008: The user can now select the number of results per page.
12/13/2007: The 2D visualization mode is back online. The 3D mode is still down.
12/03/2007: Due to temporary server restrictions, the two visualization modes are currently not available.
11/27/2007: Database update. Addition of 118 structures. The results page offers another option which generates graphs for a better visualization. For more details, check the help page.
07/27/2007: First version of the database. Online access available.
07/09/2007: New Paper: Zoé Lacroix, Christophe Legendre: Analysis of a Scientific Protocol: Selecting Suitable Resources. IEEE SCW 2007.
See the statistics page for a graphical view on the growth of the database.