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Query: PDB code = 1asu & Tool = MUpro or DFIRE or PoPMuSiC or FoldX3 or I-Mutant2 sequence only or I-Mutant2 sequence + structure or I-Mutant3 sequence only or I-Mutant3 sequence + structure

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Line Tool Res. num. Res. letter Mut. letter ΔΔG Stabilizing? Protherm Link
1 I-Mutant2 sequence + structure 1 P V 1.27 NEUTRAL
2 I-Mutant2 sequence + structure 1 P L 0.37 NEUTRAL
3 I-Mutant2 sequence + structure 1 P I 1.47 NEUTRAL
4 I-Mutant2 sequence + structure 1 P M 1.03 NEUTRAL
5 I-Mutant2 sequence + structure 1 P F 1.21 NEUTRAL
6 I-Mutant2 sequence + structure 1 P W 1.51 NEUTRAL
7 I-Mutant2 sequence + structure 1 P Y 1.44 NEUTRAL
8 I-Mutant2 sequence + structure 1 P G 1.9 NEUTRAL
9 I-Mutant2 sequence + structure 1 P A 1.68 NEUTRAL
10 I-Mutant2 sequence + structure 1 P S 1.42 NEUTRAL
11 I-Mutant2 sequence + structure 1 P T 1.16 NEUTRAL
12 I-Mutant2 sequence + structure 1 P C 1.41 NEUTRAL
13 I-Mutant2 sequence + structure 1 P H 1.1 NEUTRAL
14 I-Mutant2 sequence + structure 1 P R 0.56 NEUTRAL
15 I-Mutant2 sequence + structure 1 P K 1.06 NEUTRAL
16 I-Mutant2 sequence + structure 1 P Q 1.2 NEUTRAL
17 I-Mutant2 sequence + structure 1 P E 0.92 NEUTRAL
18 I-Mutant2 sequence + structure 1 P N 1.44 NEUTRAL
19 I-Mutant2 sequence + structure 1 P D 1.31 NEUTRAL
20 DFIRE 1 P C 0.04 NEUTRAL
21 DFIRE 1 P M 0.08 NEUTRAL
22 DFIRE 1 P F -0.23 NEUTRAL
23 DFIRE 1 P I 0.1 NEUTRAL
24 DFIRE 1 P L -0.04 NEUTRAL
25 DFIRE 1 P V 0.13 NEUTRAL
26 DFIRE 1 P W -0.54 NEUTRAL
27 DFIRE 1 P Y -0.37 NEUTRAL
28 DFIRE 1 P A 0.07 NEUTRAL
29 DFIRE 1 P G 0.13 NEUTRAL
30 DFIRE 1 P T 0.07 NEUTRAL
31 DFIRE 1 P S 0.11 NEUTRAL
32 DFIRE 1 P Q 0.07 NEUTRAL
33 DFIRE 1 P N 0.07 NEUTRAL
34 DFIRE 1 P E -0.24 NEUTRAL
35 DFIRE 1 P D -0.14 NEUTRAL
36 DFIRE 1 P H 0.1 NEUTRAL
37 DFIRE 1 P R 0.09 NEUTRAL
38 DFIRE 1 P K 0.14 NEUTRAL
39 I-Mutant2 sequence only 1 P V -0.12 NEUTRAL
40 I-Mutant2 sequence only 1 P L 0.14 NEUTRAL
41 I-Mutant2 sequence only 1 P I -0.05 NEUTRAL
42 I-Mutant2 sequence only 1 P M 0.84 NEUTRAL
43 I-Mutant2 sequence only 1 P F -0.17 NEUTRAL
44 I-Mutant2 sequence only 1 P W 0.76 NEUTRAL
45 I-Mutant2 sequence only 1 P Y 0.81 NEUTRAL
46 I-Mutant2 sequence only 1 P G 0.71 NEUTRAL
47 I-Mutant2 sequence only 1 P A 0.7 NEUTRAL
48 I-Mutant2 sequence only 1 P S 0.65 NEUTRAL
49 I-Mutant2 sequence only 1 P T 1.38 NEUTRAL
50 I-Mutant2 sequence only 1 P C 0.62 NEUTRAL
51 I-Mutant2 sequence only 1 P H 0.91 NEUTRAL
52 I-Mutant2 sequence only 1 P R -0.07 NEUTRAL
53 I-Mutant2 sequence only 1 P K 0.43 NEUTRAL
54 I-Mutant2 sequence only 1 P Q 1.05 NEUTRAL
55 I-Mutant2 sequence only 1 P E 0.17 NEUTRAL
56 I-Mutant2 sequence only 1 P N 1.18 NEUTRAL
57 I-Mutant2 sequence only 1 P D 0.85 NEUTRAL
58 PoPMuSiC 1 P A 0.51 NEUTRAL
59 PoPMuSiC 1 P C 0.36 NEUTRAL
60 PoPMuSiC 1 P D 0.54 NEUTRAL
61 PoPMuSiC 1 P E 0.4 NEUTRAL
62 PoPMuSiC 1 P F 0.4 NEUTRAL
63 PoPMuSiC 1 P G 0.15 NEUTRAL
64 PoPMuSiC 1 P H 0.42 NEUTRAL
65 PoPMuSiC 1 P I 0.31 NEUTRAL
66 PoPMuSiC 1 P K 0.27 NEUTRAL
67 PoPMuSiC 1 P L 0.37 NEUTRAL
68 PoPMuSiC 1 P M 0.32 NEUTRAL
69 PoPMuSiC 1 P N 0.4 NEUTRAL
70 PoPMuSiC 1 P Q 0.36 NEUTRAL
71 PoPMuSiC 1 P R 0.36 NEUTRAL
72 PoPMuSiC 1 P S 0.45 NEUTRAL
73 PoPMuSiC 1 P T 0.3 NEUTRAL
74 PoPMuSiC 1 P V 0.27 NEUTRAL
75 PoPMuSiC 1 P W 0.49 NEUTRAL
76 PoPMuSiC 1 P Y 0.38 NEUTRAL
77 MUpro 1 P E -0.040391 NEUTRAL
78 MUpro 1 P F -0.371555 NEUTRAL
79 MUpro 1 P I -0.86205 NEUTRAL
80 MUpro 1 P L -0.834176 NEUTRAL
81 MUpro 1 P M -0.436932 NEUTRAL
82 MUpro 1 P V -0.363082 NEUTRAL
83 MUpro 1 P Y -0.139328 NEUTRAL
84 MUpro 1 P A 0.649939 NEUTRAL
85 MUpro 1 P C 0.370707 NEUTRAL
86 MUpro 1 P D 0.328525 NEUTRAL
87 MUpro 1 P G 1.44825 NEUTRAL
88 MUpro 1 P H 0.79989 NEUTRAL
89 MUpro 1 P K 0.783981 NEUTRAL
90 MUpro 1 P N 0.494152 NEUTRAL
91 MUpro 1 P Q 0.370908 NEUTRAL
92 MUpro 1 P R 0.280758 NEUTRAL
93 MUpro 1 P S 0.712645 NEUTRAL
94 MUpro 1 P T 0.79943 NEUTRAL
95 MUpro 1 P W 0.295327 NEUTRAL
96 I-Mutant2 sequence + structure 2 L V 0.73 NEUTRAL
97 I-Mutant2 sequence + structure 2 L I 0.83 NEUTRAL
98 I-Mutant2 sequence + structure 2 L M 0.49 NEUTRAL
99 I-Mutant2 sequence + structure 2 L F 0.91 NEUTRAL
100 I-Mutant2 sequence + structure 2 L W 0.24 NEUTRAL
101 I-Mutant2 sequence + structure 2 L Y 0.37 NEUTRAL
102 I-Mutant2 sequence + structure 2 L G 0.9 NEUTRAL
103 I-Mutant2 sequence + structure 2 L A 1.1 NEUTRAL
104 I-Mutant2 sequence + structure 2 L P 0.26 NEUTRAL
105 I-Mutant2 sequence + structure 2 L S 0.85 NEUTRAL
106 I-Mutant2 sequence + structure 2 L T 1.45 NEUTRAL
107 I-Mutant2 sequence + structure 2 L C 1.41 NEUTRAL
108 I-Mutant2 sequence + structure 2 L H 0.53 NEUTRAL
109 I-Mutant2 sequence + structure 2 L R 0.01 NEUTRAL
110 I-Mutant2 sequence + structure 2 L K 0.7 NEUTRAL
111 I-Mutant2 sequence + structure 2 L Q 0.76 NEUTRAL
112 I-Mutant2 sequence + structure 2 L E 0.31 NEUTRAL
113 I-Mutant2 sequence + structure 2 L N 0.49 NEUTRAL
114 I-Mutant2 sequence + structure 2 L D 0.88 NEUTRAL
115 DFIRE 2 L C -0.02 NEUTRAL
116 DFIRE 2 L M 0.16 NEUTRAL
117 DFIRE 2 L F -0.08 NEUTRAL
118 DFIRE 2 L I 0.15 NEUTRAL
119 DFIRE 2 L V 0.15 NEUTRAL
120 DFIRE 2 L W -0.49 NEUTRAL
121 DFIRE 2 L Y -0.48 NEUTRAL
122 DFIRE 2 L A 0.15 NEUTRAL
123 DFIRE 2 L G 0.19 NEUTRAL
124 DFIRE 2 L T -0.01 NEUTRAL
125 DFIRE 2 L S 0.05 NEUTRAL
126 DFIRE 2 L Q -0.18 NEUTRAL
127 DFIRE 2 L N -0.13 NEUTRAL
128 DFIRE 2 L E -0.3 NEUTRAL
129 DFIRE 2 L D -0.27 NEUTRAL
130 DFIRE 2 L H -0.09 NEUTRAL
131 DFIRE 2 L R -0.29 NEUTRAL
132 DFIRE 2 L K -0.15 NEUTRAL
133 DFIRE 2 L P 0.32 NEUTRAL
134 I-Mutant2 sequence only 2 L V 0.17 NEUTRAL
135 I-Mutant2 sequence only 2 L I 0.36 NEUTRAL
136 I-Mutant2 sequence only 2 L M 1.11 NEUTRAL
137 I-Mutant2 sequence only 2 L F -0.14 NEUTRAL
138 I-Mutant2 sequence only 2 L W 0.01 NEUTRAL
139 I-Mutant2 sequence only 2 L Y 0.06 NEUTRAL
140 I-Mutant2 sequence only 2 L G 3.5 NO
141 I-Mutant2 sequence only 2 L A 2.04 NO
142 I-Mutant2 sequence only 2 L P 0.47 NEUTRAL
143 I-Mutant2 sequence only 2 L S 2.17 NO
144 I-Mutant2 sequence only 2 L T 3.68 NO
145 I-Mutant2 sequence only 2 L C 2.69 NO
146 I-Mutant2 sequence only 2 L H 1.15 NEUTRAL
147 I-Mutant2 sequence only 2 L R 1.12 NEUTRAL
148 I-Mutant2 sequence only 2 L K 1.82 NEUTRAL
149 I-Mutant2 sequence only 2 L Q 1.59 NEUTRAL
150 I-Mutant2 sequence only 2 L E 0.77 NEUTRAL
151 I-Mutant2 sequence only 2 L N 2.35 NO
152 I-Mutant2 sequence only 2 L D 2.64 NO
153 MUpro 2 L A 2.1896 NO
154 MUpro 2 L C 1.29785 NEUTRAL
155 MUpro 2 L D 1.42214 NEUTRAL
156 MUpro 2 L E 1.05493 NEUTRAL
157 MUpro 2 L F 0.661765 NEUTRAL
158 MUpro 2 L G 2.28864 NO
159 MUpro 2 L H 1.7602 NEUTRAL
160 MUpro 2 L I 0.255803 NEUTRAL
161 MUpro 2 L K 1.7346 NEUTRAL
162 MUpro 2 L M 0.422111 NEUTRAL
163 MUpro 2 L N 1.42318 NEUTRAL
164 MUpro 2 L P 1.69058 NEUTRAL
165 MUpro 2 L Q 1.36495 NEUTRAL
166 MUpro 2 L R 1.37892 NEUTRAL
167 MUpro 2 L S 1.66636 NEUTRAL
168 MUpro 2 L T 1.93235 NEUTRAL
169 MUpro 2 L V 0.462265 NEUTRAL
170 MUpro 2 L W 1.25751 NEUTRAL
171 MUpro 2 L Y 1.01679 NEUTRAL
172 PoPMuSiC 2 L A 0.34 NEUTRAL
173 PoPMuSiC 2 L C 0.22 NEUTRAL
174 PoPMuSiC 2 L D 0.47 NEUTRAL
175 PoPMuSiC 2 L E 0.48 NEUTRAL
176 PoPMuSiC 2 L F 0.22 NEUTRAL
177 PoPMuSiC 2 L G 0.67 NEUTRAL
178 PoPMuSiC 2 L H 0.35 NEUTRAL
179 PoPMuSiC 2 L I 0.31 NEUTRAL
180 PoPMuSiC 2 L K 0.4 NEUTRAL
181 PoPMuSiC 2 L M 0.44 NEUTRAL
182 PoPMuSiC 2 L N 0.46 NEUTRAL
183 PoPMuSiC 2 L P -0.36 NEUTRAL
184 PoPMuSiC 2 L Q 0.33 NEUTRAL
185 PoPMuSiC 2 L R 0.4 NEUTRAL
186 PoPMuSiC 2 L S 0.31 NEUTRAL
187 PoPMuSiC 2 L T 0.29 NEUTRAL
188 PoPMuSiC 2 L V 0.32 NEUTRAL
189 PoPMuSiC 2 L W 0.16 NEUTRAL
190 PoPMuSiC 2 L Y 0.25 NEUTRAL


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Visualization:

Using the native 3D structure with colored residues highlighting ΔΔG changes.

Warning! The 3D visualization requires running Java, which may be disabled on your system due to default security settings. Please see Java's page on the Exception Site List for instructions on how to enable the applet by adding the URL as an exception.

By graphs superposition representing ΔΔG along the sequence for each tool (Only available without any conditions on the residue or mutation type)

CSV file: You can also download these results in csv format here.

Table Notes:

  • A YES under 'Stabilizing?' means that the mutation is more favorable than the wild residue to the stability of the protein in terms of energy.
  • A NO under 'Stabilizing?' means that the mutation is less favorable than the wild residue to the stability of the protein in terms of energy.
  • A NEUTRAL under 'Stabilizing?' means that the magnitude of ΔΔG associated with mutation is less than the required threshold.
  • When available, a link to the corresponding Protherm entry is provided.
  • When you click on a column header, results will be sorted by the criterion.
  • ΔΔG unit is kcal/mol.

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